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The purpose of this study is to explore the genocidal impacts of uranium mining for Native Americans in the Northwest and Northern Plains, as well as their resistance to historical and contemporary acts of colonialism.

Using a case study approach, this study gathered qualitative data from various government, tribal and news sources to investigate the extent of ecological violence experienced by Native Americans specific to uranium mining processes on Spokane Indian Reservation, Pine Ridge Reservation and Wind River Reservation.

Native Americans in the Northwest and Northern Plains are victimized by the capitalism-genocide involved in uranium production. The consequences of the uranium industry boom in the 1950s–1980s has left Native Americans with degraded lands, polluted water sources and a legacy of adverse health effects, including some of the highest rates of cancer.

The work discussed in this paper offers possibilities for collaborating with Native Americans to develop more sustainable energy options for the USA to make the necessary shift away from fossil fuels and nuclear energy.

Prior research has addressed the genocidal impacts of uranium mining for Native Americans in the Southwest USA and claimed these actions were direct consequences of toxic colonialism, capitalistic agendas and the treadmill of production (Fegadel, 2023). Most uranium was recovered from ore deposits within the Colorado Plateau, and most abandoned uranium mines (AUMs) are located within the same region. Tribes residing in the Northwest and Northern Plains have, however, experienced similar plights as those in the Southwest, but these issues have not been widely examined.